- Products & Services
OrganRXTM Tissue builds quality, transplantable tissue for organ repair needs. Using the advanced biomimetic OrganRXTM technologies allows for the construction of functional organ tissue for therapeutic discoveries.
The multi-organ recirculation system (OrganRXTM) provides passive gravity-driven unidirectional shear flow to multi-organ culture. The OrganRXTM plate can accommodate multiple micro-organs such as liver, gut, kidney and brain.
The organ plate is an injection molded glass bottom disposable plate. The users can populate the plate with primary cells, cell lines or IPS cells and mature organs by media recirculation. Currently the plate has six multi-organ units.
We provide testing of compounds in 2-D and 3-D blood-brain-barrier tissue models. OrganRXTM enables determination of transport characteristics of novel compounds to/from the brain and other organs. - Applications
Applications
OrganRXTM helps to recapitulate human organs with physiological, mechanical and biochemical complexities and their interaction through the exchange of metabolites or signaling molecules and selective transport across the barriers.
Organ Functions
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Technology
Biopico’s innovation involves the development of endothelium-epithelium interface using Laplace fluidic-stop channels and fluidic programming using gravity-driven unidirectional recirculation of media. This enables layering of extracellular matrix gel and tissues without using artificial membranes, allowing co-culture of endothelium with epithelium and the free migration of immune cells through the extracellular matrix gel. Further, multidimensional tilting of the OrganRX plate produces periodic recirculation with programmable resident times across organs that are connected in series and parallel. The system can also integrate multiple individual organs or organoids developed in traditional culture protocols into the OrganRX plate.
