- Products & Services
OrganRXTM Tissue builds quality, transplantable tissue for organ repair needs. Using the advanced biomimetic OrganRXTM technologies allows for the construction of functional organ tissue for therapeutic discoveries.
The multi-organ recirculation system (OrganRXTM) provides passive gravity-driven unidirectional shear flow to multi-organ culture. The OrganRXTM plate can accommodate multiple micro-organs such as liver, gut, kidney and brain.
The organ plate is an injection molded glass bottom disposable plate. The users can populate the plate with primary cells, cell lines or IPS cells and mature organs by media recirculation. Currently the plate has six multi-organ units.
We provide testing of compounds in 2-D and 3-D blood-brain-barrier tissue models. OrganRXTM enables determination of transport characteristics of novel compounds to/from the brain and other organs. - Applications
Applications
OrganRXTM helps to recapitulate human organs with physiological, mechanical and biochemical complexities and their interaction through the exchange of metabolites or signaling molecules and selective transport across the barriers.
Organ Functions
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Barrier Functions
Barriers between organs and fluid systems exist throughout the body to selectively regulate the movement of compounds through membranes. One example is the blood-brain barrier, which modulates what molecules and compounds can travel from the bloodstream to the brain through layers of epithelial cells, endothelial cells, pericytes, and astrocytes. The intestine barrier allows the microbiome of the gut to absorb and process nutrients while not leaking into the blood or other organs.
Selectivity across physiological barriers is crucial to assess for applications like drug delivery since therapeutics have to cross several barriers to reach target sites effectively. Culturing cells on microfluidic chips with dynamic flow promote cells to perform in vivo-like functionalities, which in turn allow accurate, translatable measurements of parameters like transepithelial/transendothelial resistance (TEER).
