- Products & Services
OrganRXTM Tissue builds quality, transplantable tissue for organ repair needs. Using the advanced biomimetic OrganRXTM technologies allows for the construction of functional organ tissue for therapeutic discoveries.
The multi-organ recirculation system (OrganRXTM) provides passive gravity-driven unidirectional shear flow to multi-organ culture. The OrganRXTM plate can accommodate multiple micro-organs such as liver, gut, kidney and brain.
The organ plate is an injection molded glass bottom disposable plate. The users can populate the plate with primary cells, cell lines or IPS cells and mature organs by media recirculation. Currently the plate has six multi-organ units.
We provide testing of compounds in 2-D and 3-D blood-brain-barrier tissue models. OrganRXTM enables determination of transport characteristics of novel compounds to/from the brain and other organs. - Applications
Applications
OrganRXTM helps to recapitulate human organs with physiological, mechanical and biochemical complexities and their interaction through the exchange of metabolites or signaling molecules and selective transport across the barriers.
Organ Functions
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ADME-Tox
The life cycle of drug compounds in the body includes administration, distribution, metabolism, and excretion (ADME). Each of these steps occurs in one or more organs when the drug flows through the body, which includes the gut, liver, and kidney. But as the therapeutic compounds are processed, they are broken down into metabolites and waste products that may affect each organ differently.
In order for therapeutics to reach target sites, they must efficiently pass through barriers on and between organs and vasculature. It is also critical to ensure that metabolites of therapeutic compounds are not toxic to the organs processing them. Three-dimensional, flow-driven culture platforms like organ chip allow not only multiple cell types to form organ-like structures but also concurrent analysis of drug flow from organ to organ.
