- Products & Services
OrganRXTM Tissue builds quality, transplantable tissue for organ repair needs. Using the advanced biomimetic OrganRXTM technologies allows for the construction of functional organ tissue for therapeutic discoveries.
The multi-organ recirculation system (OrganRXTM) provides passive gravity-driven unidirectional shear flow to multi-organ culture. The OrganRXTM plate can accommodate multiple micro-organs such as liver, gut, kidney and brain.
The organ plate is an injection molded glass bottom disposable plate. The users can populate the plate with primary cells, cell lines or IPS cells and mature organs by media recirculation. Currently the plate has six multi-organ units.
We provide testing of compounds in 2-D and 3-D blood-brain-barrier tissue models. OrganRXTM enables determination of transport characteristics of novel compounds to/from the brain and other organs. - Applications
Applications
OrganRXTM helps to recapitulate human organs with physiological, mechanical and biochemical complexities and their interaction through the exchange of metabolites or signaling molecules and selective transport across the barriers.
Organ Functions
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Brain-Gut Plate
The brain and gut have been shown to influence each other in a number of ways, one of which is the travel of secreted signaling compounds via the bloodstream. Signals and compounds induced or secreted from the complex microbiota of the gut can induce effects in the brain, which can play into the progression of neuropathological conditions.
Due to the complexities of both organs, culturing both types on a single platform can be difficult. Animal models do not address the bi-directionality of communication between the brain and gut. Ecological differences between animals and humans, particularly in the composition of the gut microbiota, cause data from animal models not to be accurately comparable to human trials.
In vitro models with three-dimensional, microfluidic environments allow cells to grow to in vivo functionality. With dynamic in vivo fluid flow, these models also permit the study of gut and brain barriers with mechanical factors like shear stress.
