- Products & Services
OrganRXTM Tissue builds quality, transplantable tissue for organ repair needs. Using the advanced biomimetic OrganRXTM technologies allows for the construction of functional organ tissue for therapeutic discoveries.
The multi-organ recirculation system (OrganRXTM) provides passive gravity-driven unidirectional shear flow to multi-organ culture. The OrganRXTM plate can accommodate multiple micro-organs such as liver, gut, kidney and brain.
The organ plate is an injection molded glass bottom disposable plate. The users can populate the plate with primary cells, cell lines or IPS cells and mature organs by media recirculation. Currently the plate has six multi-organ units.
We provide testing of compounds in 2-D and 3-D blood-brain-barrier tissue models. OrganRXTM enables determination of transport characteristics of novel compounds to/from the brain and other organs. - Applications
Applications
OrganRXTM helps to recapitulate human organs with physiological, mechanical and biochemical complexities and their interaction through the exchange of metabolites or signaling molecules and selective transport across the barriers.
Organ Functions
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Infection
When microbes infect cells, they often signal the immune system to manage the infection. Infected cells from one organ can also implicate other organs from crosstalk and fluid flow of signaling molecules and immune markers. Infection involves complex pathways between organs and organ systems and provokes immune responses that impact tissues in a variety of ways, like inducing inflammation.
Culturing multiple organs along with components of the immune system on microfluidic devices provides a platform to assess the dynamic mechanisms and effects of infection. The stages and properties of infection of a variety of infectious agents can be analyzed on these platforms, from microbial colonization and invasion to multi-organ pathological outcomes and drug interactions. They also provide a model for infectious diseases, revealing intricate interactions between host and pathogen from the time of infection to treatment.
