- Products & Services
OrganRXTM Tissue builds quality, transplantable tissue for organ repair needs. Using the advanced biomimetic OrganRXTM technologies allows for the construction of functional organ tissue for therapeutic discoveries.
The multi-organ recirculation system (OrganRXTM) provides passive gravity-driven unidirectional shear flow to multi-organ culture. The OrganRXTM plate can accommodate multiple micro-organs such as liver, gut, kidney and brain.
The organ plate is an injection molded glass bottom disposable plate. The users can populate the plate with primary cells, cell lines or IPS cells and mature organs by media recirculation. Currently the plate has six multi-organ units.
We provide testing of compounds in 2-D and 3-D blood-brain-barrier tissue models. OrganRXTM enables determination of transport characteristics of novel compounds to/from the brain and other organs. - Applications
Applications
OrganRXTM helps to recapitulate human organs with physiological, mechanical and biochemical complexities and their interaction through the exchange of metabolites or signaling molecules and selective transport across the barriers.
Organ Functions
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Microbiome
The human body relies on the microbiome to absorb nutrients, protect from pathogens, and aid in other physiological processes. Epithelial barriers that separate the microbiome from infecting the body are crucial for maintaining homeostasis. The compounds and signaling molecules that can cross through these barriers, along with the microbes that cross through weakened barriers, can contribute to the pathogenesis and progression of diseases.
The microbiome is unique to organisms that have them, and microfluidic devices allow for differences and similarities between each individual’s microbiome and resulting interactions to be analyzed in vitro. The dynamic flow recapitulates how compounds processed by the microbiota interact with other organs. Culturing a microbiota along with barriers lined with endothelial cells allows for the study of barrier integrity, shear stress, and selectivity.
