- Products & Services
OrganRXTM Tissue builds quality, transplantable tissue for organ repair needs. Using the advanced biomimetic OrganRXTM technologies allows for the construction of functional organ tissue for therapeutic discoveries.
The multi-organ recirculation system (OrganRXTM) provides passive gravity-driven unidirectional shear flow to multi-organ culture. The OrganRXTM plate can accommodate multiple micro-organs such as liver, gut, kidney and brain.
The organ plate is an injection molded glass bottom disposable plate. The users can populate the plate with primary cells, cell lines or IPS cells and mature organs by media recirculation. Currently the plate has six multi-organ units.
We provide testing of compounds in 2-D and 3-D blood-brain-barrier tissue models. OrganRXTM enables determination of transport characteristics of novel compounds to/from the brain and other organs. - Applications
Applications
OrganRXTM helps to recapitulate human organs with physiological, mechanical and biochemical complexities and their interaction through the exchange of metabolites or signaling molecules and selective transport across the barriers.
Organ Functions
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Angiogenesis
Angiogenesis is the formation of new blood vessels in the body. Blood vessels are critical for carrying nutrients, oxygen, and waste for organs, and angiogenesis around organs ensures sufficient function and circulation. Blood vessels also carry signaling molecules that promote the growth and maturation of organs. Angiogenesis can occur around tumors as well, facilitating cancer growth and possible metastasis.
New blood vessels can be cultured and tested for integrity and fluid flow capacity in three-dimensional microfluidic devices. When cultured along organs, the interactions and flow of compounds between developing blood vasculature and organs can be assessed. Microfluidic platforms can also investigate the role of angiogenesis in sustaining cancerous tumors or the pharmacological activity of pro-/anti-angiogenesis drugs.
