- Products & Services
OrganRXTM Tissue builds quality, transplantable tissue for organ repair needs. Using the advanced biomimetic OrganRXTM technologies allows for the construction of functional organ tissue for therapeutic discoveries.
The multi-organ recirculation system (OrganRXTM) provides passive gravity-driven unidirectional shear flow to multi-organ culture. The OrganRXTM plate can accommodate multiple micro-organs such as liver, gut, kidney and brain.
The organ plate is an injection molded glass bottom disposable plate. The users can populate the plate with primary cells, cell lines or IPS cells and mature organs by media recirculation. Currently the plate has six multi-organ units.
We provide testing of compounds in 2-D and 3-D blood-brain-barrier tissue models. OrganRXTM enables determination of transport characteristics of novel compounds to/from the brain and other organs. - Applications
Applications
OrganRXTM helps to recapitulate human organs with physiological, mechanical and biochemical complexities and their interaction through the exchange of metabolites or signaling molecules and selective transport across the barriers.
Organ Functions
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Inflammation
Inflammatory pathways are incredibly complex and can implicate multiple organs in the body. Inflammation in one organ can cause downstream effects in another organ as inflammatory markers flow through the body. Several inflammatory processes can also further disease progression or trigger protective effects in organs. In organs like the intestine, microbial factors can enhance or suppress inflammatory pathways that eventually affect neurodegenerative conditions.
Comprehensive analysis of inflammation requires platforms that can spatially culture multiple organs. In vivo, inflammatory markers flow from organ to organ, which can be modeled with microfluidics. The inflammatory mechanisms of organs switching from steady to inflammatory states can also be observed on three-dimensional, dynamic platforms. These platforms also permit the study of organ damage induced by inflammatory pathways.
