- Products & Services
OrganRXTM Tissue builds quality, transplantable tissue for organ repair needs. Using the advanced biomimetic OrganRXTM technologies allows for the construction of functional organ tissue for therapeutic discoveries.
The multi-organ recirculation system (OrganRXTM) provides passive gravity-driven unidirectional shear flow to multi-organ culture. The OrganRXTM plate can accommodate multiple micro-organs such as liver, gut, kidney and brain.
The organ plate is an injection molded glass bottom disposable plate. The users can populate the plate with primary cells, cell lines or IPS cells and mature organs by media recirculation. Currently the plate has six multi-organ units.
We provide testing of compounds in 2-D and 3-D blood-brain-barrier tissue models. OrganRXTM enables determination of transport characteristics of novel compounds to/from the brain and other organs. - Applications
Applications
OrganRXTM helps to recapitulate human organs with physiological, mechanical and biochemical complexities and their interaction through the exchange of metabolites or signaling molecules and selective transport across the barriers.
Organ Functions
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Cancer Metastasis
Cancer metastasis occurs when cancerous cells grow into malignant tumors and eventually traverse to regions beyond their origin. These malignant cells often travel via the vasculature of the body, and they find ways to cross multi-cellular barriers between organs. When healthy cells detect cancer cells in fluid and/or organs, they can elicit physiological responses that aid or fight further infection.
To understand the stages of tumor progression to metastasis of cancerous cells, platforms that simulate physiological fluid flow are necessary to observe how these cells reach other organs and what effects their presence may signal in these organs. In addition, when cancer growths progress to tumors, they require three-dimensional microenvironments. Microfluidic devices address these conditions, allowing the study of metastasizing cancer cells as they flow from the original tumor site to various organs.
