- Products & Services
OrganRXTM Tissue builds quality, transplantable tissue for organ repair needs. Using the advanced biomimetic OrganRXTM technologies allows for the construction of functional organ tissue for therapeutic discoveries.
The multi-organ recirculation system (OrganRXTM) provides passive gravity-driven unidirectional shear flow to multi-organ culture. The OrganRXTM plate can accommodate multiple micro-organs such as liver, gut, kidney and brain.
The organ plate is an injection molded glass bottom disposable plate. The users can populate the plate with primary cells, cell lines or IPS cells and mature organs by media recirculation. Currently the plate has six multi-organ units.
We provide testing of compounds in 2-D and 3-D blood-brain-barrier tissue models. OrganRXTM enables determination of transport characteristics of novel compounds to/from the brain and other organs. - Applications
Applications
OrganRXTM helps to recapitulate human organs with physiological, mechanical and biochemical complexities and their interaction through the exchange of metabolites or signaling molecules and selective transport across the barriers.
Organ Functions
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Kidney plate
The kidney exists in a dynamic microenvironment, depending on molecular and pressure gradients to function. Since the kidney is largely involved in hemodynamics, it also plays a critical role in the excretion/clearance of drug compounds. Because of this, in vitro models that account for dynamic fluid flow provide the most suitable platform for cells to exhibit tissue-like properties.
Due to the complexity of the cell systems and functional roles of the kidney, current static, 2-D culture systems limit renal cell growth . Cells grown in these culture conditions make it difficult to screen drugs that may be nephrotoxic due to their low functionality. Translating data from these in vitro models to animal or human testing also creates gaps in knowledge.
The dynamic flow delivered by microfluidic models promotes kidney cell cytostructure and tight junctions to form organs. The 3-D aspect of these models also facilitates renal cells to form with improved morphology compared to static, two-dimensional models.
