Author: admin@bio
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Toxicity
To evaluate model human toxicity, linking metabolism, cross-organ effects, safety biomarkers, and therapeutics
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Cancer-Immune Model
To evaluate immunotherapy efficacy, checkpoint blockade, and systemic toxicity in human conditions.
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Islets-Immune Model
To evaluate protective strategies from immune rejection of islet transplants.
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Liver-Brain Model
To connect drug metabolism with investigations of drug safety, neurotoxicity and diseases.
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BBB-Brain Model
To model neurovascular function, disease conditions, and drug transport across barriers.
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Fluidic Programmable Gravi-maze Array for High Throughput Multiorgan Drug Testing
Henry C. Wong, Chris J. Collins, Joshna A. Jude Jose, Isha N. Bhakta, Andrew J. Collins, Gunjan Katara, Johar Kohana, Harpreet S. Saluja, John Collins, Fluidic Programmable Gravi-maze Array for High Throughput Multiorgan Drug Testing BioRxiv 2025.06.18.660241; doi: https://doi.org/10.1101/2025.06.18.660241
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Advancing Senescence-Based In Vitro Drug Testing for Alzheimer’s Disease: Targeting Aβ and p-Tau Models in a Gut-Liver-Brain Multiorgan System
J. COLLINS, H. WONG, G. KATARA, J. KOHANA, J. A. J. JOSE, C. J. COLLINS, A. J. COLLINS; Biopico Systems Inc, Irvine, CA, Advancing Senescence-Based In Vitro Drug Testing for Alzheimer’s Disease: Targeting Aβ and p-Tau Models in a Gut-Liver-Brain Multiorgan System, Society of Neuroscience Annual Meeting,Washington DC (2023).
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BBB Form
Online Admission Registration BBB ORGAN Name E-mail Id Number of units per plate Materials for making Fibrinogen gel Fibrinogen working solution concentration Fibrinogen powder PBS Materials for making Thrombin gel Stock solution of Thrombin NIH U/mg Protein U/mg Solid Solid in bottle Units in bottle Concentration of Thrombin liquid after dissolving in 1ml PBS Required…
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Continuous Transepithelial-endothelial measurements
J. Collins1, H. C. Wong1, A. J. Collins1,2, G. Katara1, C. J. Collins1,2, J. A. J. Jose1,2,#, J. Kohana1, M. Sun1, K. V. Johnston1, S. L. Lim2, M. Kitazawa2, T. Teafatiller2, V. Subramanian2; 1Biopico Systems Inc, Irvine, CA; 2Univ. Of California Irvine, Irvine, CA, #Presenting Author. Continuous Transepithelial-endothelial measurements to track blood-brain-barrier integrity in a…
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Inflammation
To replicate systemic inflammation, linking vascular, immune, and parenchymal tissues to study therapies.