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Better human predictive models needed for preclinical drug development

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[bt_bb_card_image lazy_load=”no” html_tag=”h3″ size=”extrasmall” background_color=”” image=”4114″ supertitle=”” title=”ORGANRXTM RECIRCULATION SYSTEM” subtitle=”” text=”Provides shear flow to multi-organ culture” url=”services” target=”_self” style=”” border=”show” shadow=”show” color_scheme=”” responsive=”” publish_datetime=”” expiry_datetime=”” el_id=”” el_class=”” el_style=”” background_color_scheme=”” animation=”no_animation”]
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[bt_bb_card_image lazy_load=”no” html_tag=”h3″ size=”extrasmall” background_color=”” image=”4112″ supertitle=”” title=”ORGAN TEER MEASUREMENT SYSTEM” subtitle=”” text=”Remote monitoring organ barrier using TEER” url=”services” target=”_self” style=”” border=”” shadow=”show” color_scheme=”” responsive=”” publish_datetime=”” expiry_datetime=”” el_id=”” el_class=”” el_style=”” background_color_scheme=”” animation=”no_animation”]
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[bt_bb_card_image lazy_load=”no” html_tag=”h3″ size=”extrasmall” background_color=”” image=”4111″ supertitle=”” title=”ORGANRXTM DISPOSABLE PLATE” subtitle=”” text=”Culturing vascularized interacting organs” url=”services” target=”_self” style=”” border=”show” shadow=”show” color_scheme=”” responsive=”” publish_datetime=”” expiry_datetime=”” el_id=”” el_class=”” el_style=”” background_color_scheme=”” animation=”no_animation”]
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OrganRXTM: Organ RecapitulatorHuman-relevant organ recapitulator

Our organ models enable researchers to recapitulate human biology by populating organ-specific 3-D matrices, tissue specific cells and applying fluidic shear stress. The organ system provides high throughput imaging capability, electrical measurement, effluent analysis and gene expression analysis.

The OrganRXTM System

Our OrganRXTM System provides recirculation of media across multiple organs with a specified fluidic shear stress for the recapitulation of organs. The OrganRXTM system is operated by a smartphone.

The system provides passive gravity-driven unidirectional shear flow to multi-organ culture. The OrganRXTM plate can accommodate multiple micro-organs such as liver, gut, kidney and brain.

The OrganRXTM products are injection molded glass bottom disposable plate, stainless steel recirculation system and control app.

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APPLICATIONSOrgan Functions

[bt_bb_card_image lazy_load=”no” html_tag=”h4″ size=”medium” background_color=”” image=”3928″ supertitle=”” title=”Barrier Functions” subtitle=”” text=”Test the formation, maintenance, and integrity of tight junctions in cellular barriers.” url=”barrier-function” target=”_self” style=”rectangle” border=”show” shadow=”show” color_scheme=”” responsive=”” publish_datetime=”” expiry_datetime=”” el_id=”” el_class=”” el_style=”” background_color_scheme=”” animation=”no_animation”]
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[bt_bb_card_image lazy_load=”no” html_tag=”h3″ size=”medium” background_color=”” image=”3926″ supertitle=”” title=”ADME-Tox” subtitle=”” text=”Evaluate the absorbance, distribution, metabolism, excretion and toxicity of compounds flowing through organs.” url=”adme-tox-function” target=”_self” style=”rectangle” border=”show” shadow=”show” color_scheme=”” responsive=”” publish_datetime=”” expiry_datetime=”” el_id=”” el_class=”” el_style=”” background_color_scheme=”” animation=”no_animation”]
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[bt_bb_card_image lazy_load=”no” html_tag=”h3″ size=”medium” background_color=”” image=”3929″ supertitle=”” title=”Cancer” subtitle=”” text=”Assess the progression of cancerous tumors, and how these growth utilize vasculature and affect different organs.” url=”cancer-metastasis-function” target=”_self” style=”rectangle” border=”show” shadow=”show” color_scheme=”” responsive=”” publish_datetime=”” expiry_datetime=”” el_id=”” el_class=”” el_style=”” background_color_scheme=”” animation=”no_animation”]
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[bt_bb_card_image lazy_load=”no” html_tag=”h3″ size=”medium” background_color=”” image=”3932″ supertitle=”” title=”Inflammation” subtitle=”” text=”Stimulate inflammation to observe the downstream effects of triggered inflammatory markers as they flow from organ to organ.” url=”inflammation-function” target=”_self” style=”rectangle” border=”show” shadow=”show” color_scheme=”” responsive=”” publish_datetime=”” expiry_datetime=”” el_id=”” el_class=”” el_style=”” background_color_scheme=”” animation=”no_animation”]
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[bt_bb_card_image lazy_load=”no” html_tag=”h3″ size=”medium” background_color=”” image=”3931″ supertitle=”” title=”Infection” subtitle=”” text=”Analyze the immune responses for organs invoked by infection from pathogens and foreign agents.” url=”infection-function” target=”_self” style=”rectangle” border=”show” shadow=”show” color_scheme=”” responsive=”” publish_datetime=”” expiry_datetime=”” el_id=”” el_class=”” el_style=”” background_color_scheme=”” animation=”no_animation”]
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[bt_bb_card_image lazy_load=”no” html_tag=”h3″ size=”medium” background_color=”” image=”3933″ supertitle=”” title=”Microbiome” subtitle=”” text=”Observe interactions between microbiota and cellular barriers during nutrient absorption.” url=”microbiome-function” target=”_self” style=”rectangle” border=”show” shadow=”show” color_scheme=”” responsive=”” publish_datetime=”” expiry_datetime=”” el_id=”” el_class=”” el_style=”” background_color_scheme=”” animation=”no_animation”]
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[bt_bb_card_image lazy_load=”no” html_tag=”h3″ size=”medium” background_color=”” image=”3935″ supertitle=”” title=”Vasculogensis” subtitle=”” text=”Test factors affecting the construction and upkeep of vascular networks providing fluid flow.” url=”vasculogenesis-function” target=”_self” style=”rectangle” border=”show” shadow=”show” color_scheme=”” responsive=”” publish_datetime=”” expiry_datetime=”” el_id=”” el_class=”” el_style=”” background_color_scheme=”” animation=”no_animation”]
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[bt_bb_card_image lazy_load=”no” html_tag=”h3″ size=”medium” background_color=”” image=”3930″ supertitle=”” title=”Extravasation” subtitle=”” text=”Assess how leaked fluids from compromised vasculature and cell barriers affect surrounding organs.” url=”extravasation-function” target=”_self” style=”rectangle” border=”show” shadow=”show” color_scheme=”” responsive=”” publish_datetime=”” expiry_datetime=”” el_id=”” el_class=”” el_style=”” background_color_scheme=”” animation=”no_animation”]
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[bt_bb_card_image lazy_load=”no” html_tag=”h3″ size=”medium” background_color=”” image=”3927″ supertitle=”” title=”Angiogenesis” subtitle=”” text=”Observe the branching of blood vasculature to support developing organs or tumors.” url=”angiogenesis-function” target=”_self” style=”rectangle” border=”show” shadow=”show” color_scheme=”” responsive=”” publish_datetime=”” expiry_datetime=”” el_id=”” el_class=”” el_style=”” background_color_scheme=”” animation=”no_animation”]
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Organ Models

[bt_bb_card_image lazy_load=”no” html_tag=”h3″ size=”medium” background_color=”” image=”4725″ supertitle=”” title=”BBB Plate” subtitle=”” text=”Model the crucial barrier protecting sensitive brain tissue from compounds flowing through blood.” url=”bbb-plate” target=”_self” style=”rectangle” border=”show” shadow=”show” color_scheme=”” responsive=”” publish_datetime=”” expiry_datetime=”” el_id=”” el_class=”” el_style=”” background_color_scheme=”” animation=”no_animation”]
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[bt_bb_card_image lazy_load=”no” html_tag=”h3″ size=”medium” background_color=”” image=”4726″ supertitle=”” title=”Brain Plate” subtitle=”” text=”Assemble glial cells and neurons to model a functional brain, and assess compound toxicity and electrophysiology.” url=”brain-plate” target=”_self” style=”rectangle” border=”show” shadow=”show” color_scheme=”” responsive=”” publish_datetime=”” expiry_datetime=”” el_id=”” el_class=”” el_style=”” background_color_scheme=”” animation=”no_animation”]
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[bt_bb_card_image lazy_load=”no” html_tag=”h3″ size=”medium” background_color=”” image=”4731″ supertitle=”” title=”Gut Plate” subtitle=”” text=”Observe how compounds and nutrients are absorbed in the gut and test the integrity of intestinal linings.” url=”gut-plate” target=”_self” style=”rectangle” border=”show” shadow=”show” color_scheme=”” responsive=”” publish_datetime=”” expiry_datetime=”” el_id=”” el_class=”” el_style=”” background_color_scheme=”” animation=”no_animation”]
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[bt_bb_card_image lazy_load=”no” html_tag=”h3″ size=”medium” background_color=”” image=”4733″ supertitle=”” title=”Kidney Plate” subtitle=”” text=”Test the flow of blood and subsequent compounds in renal cells, and how waste products are processed for excretion.” url=”kidney-plate” target=”_self” style=”rectangle” border=”show” shadow=”show” color_scheme=”” responsive=”” publish_datetime=”” expiry_datetime=”” el_id=”” el_class=”” el_style=”” background_color_scheme=”” animation=”no_animation”]
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[bt_bb_card_image lazy_load=”no” html_tag=”h3″ size=”medium” background_color=”” image=”4734″ supertitle=”” title=”Liver Plate” subtitle=”” text=”Analyze the detoxification and metabolization of therapeutics and toxic compounds in the liver.” url=”liver-plate” target=”_self” style=”rectangle” border=”show” shadow=”show” color_scheme=”” responsive=”” publish_datetime=”” expiry_datetime=”” el_id=”” el_class=”” el_style=”” background_color_scheme=”” animation=”no_animation”]
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[bt_bb_card_image lazy_load=”no” html_tag=”h3″ size=”medium” background_color=”” image=”4727″ supertitle=”” title=”Brain-Gut Plate” subtitle=”” text=”Observe the contributions of brain-gut axis on neuroinflammation, neurodegeneration, and other neurological processes.” url=”brain-gut-plate” target=”_self” style=”rectangle” border=”show” shadow=”show” color_scheme=”” responsive=”” publish_datetime=”” expiry_datetime=”” el_id=”” el_class=”” el_style=”” background_color_scheme=”” animation=”no_animation”]
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[bt_bb_card_image lazy_load=”no” html_tag=”h3″ size=”medium” background_color=”” image=”4729″ supertitle=”” title=”Brain-Kidney Plate” subtitle=”” text=”Model the flow of drug compounds and metabolites from molecular targets in the brain to clearance processes in the kidney.” url=”brain-kidney-plate” target=”_self” style=”rectangle” border=”show” shadow=”show” color_scheme=”” responsive=”” publish_datetime=”” expiry_datetime=”” el_id=”” el_class=”” el_style=”” background_color_scheme=”” animation=”no_animation”]
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[bt_bb_card_image lazy_load=”no” html_tag=”h3″ size=”medium” background_color=”” image=”4732″ supertitle=”” title=”Gut, Kidney, Liver Plate” subtitle=”” text=”Simulate the absorption and clearance of compounds and therapeutics as they are processed from one organ to another.” url=”gut-kidney-liver-plate” target=”_self” style=”rectangle” border=”show” shadow=”show” color_scheme=”” responsive=”” publish_datetime=”” expiry_datetime=”” el_id=”” el_class=”” el_style=”” background_color_scheme=”” animation=”no_animation”]
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[bt_bb_card_image lazy_load=”no” html_tag=”h3″ size=”medium” background_color=”” image=”4728″ supertitle=”” title=”Brain-Gut-Kidney-Liver Plate” subtitle=”” text=”Analyze the complete life cycle of toxic or therapeutic compounds as they are absorbed, processed, and utilized by multiple organs through physiological fluid flow.” url=”brain-gut-kidney-liver-plate” target=”_self” style=”rectangle” border=”show” shadow=”show” color_scheme=”” responsive=”” publish_datetime=”” expiry_datetime=”” el_id=”” el_class=”” el_style=”” background_color_scheme=”” animation=”no_animation”]
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ABOUT USOrganRXTM: Advancing Drug Discovery

Accurate biology models for precision medicine

The True Human-on-a-Plate Company

Biopico Systems Inc is a leader in the emerging field of interacting multiple organ systems or microphysiological systems technology. This technology will accurately recapitulate human physiology by engineering physiological fluidic flow and organ microenvironment. This will revolutionize in vitro biomedical research for drug discovery, disease pathology, and regenerative medicine.

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RESOURCESLearn how to apply Organ System devices to your research

Check out our publications, application notes, media, and blogs to implement Organ systems with current discoveries.
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SUPPORTNeed help with our products?

Take a look at our support tools and protocols to help address your experimental inquiries.
Accurate and precise data
Achieve high-quality results
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CONTACT USGet in Touch With Us Today

OrganRX is the best compromise between simplicity in operation and the complexity of multi-organ models.
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Contact Us

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      Contract Research ServicesTissue and Disease Models for Drug Discovery

      Collaborate
      Compound Profiling & Screening
      • Get comprehensive compound data in tissue models through our CRO services. With established assays in the OrganRXTM platform, we support your drug discovery and development needs.
      Innovate
      Custom Model & Assay Development
      • We create novel organ and disease models in the OrganRXTM platform. Develop novel assays according to your design.
      Conquer
      Drug Development Partnerships
      • Expand your drug discovery with our scientific team. Human disease biology in the OrganRXTM platform.
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