- Products & Services
OrganRXTM Tissue builds quality, transplantable tissue for organ repair needs. Using the advanced biomimetic OrganRXTM technologies allows for the construction of functional organ tissue for therapeutic discoveries.
The multi-organ recirculation system (OrganRXTM) provides passive gravity-driven unidirectional shear flow to multi-organ culture. The OrganRXTM plate can accommodate multiple micro-organs such as liver, gut, kidney and brain.
The organ plate is an injection molded glass bottom disposable plate. The users can populate the plate with primary cells, cell lines or IPS cells and mature organs by media recirculation. Currently the plate has six multi-organ units.
We provide testing of compounds in 2-D and 3-D blood-brain-barrier tissue models. OrganRXTM enables determination of transport characteristics of novel compounds to/from the brain and other organs. - Applications
Applications
OrganRXTM helps to recapitulate human organs with physiological, mechanical and biochemical complexities and their interaction through the exchange of metabolites or signaling molecules and selective transport across the barriers.
Organ Functions
MenuOrgan Models
Menu
Gut-Kidney-Liver Plate
After compounds enter the body, they are metabolized by the gut and liver and then cleared by the kidney. The interconnection and communications between these three organs contribute greatly to drug metabolism and disease progression.
Metabolic pathways and mechanisms between the gut, kidney, and liver are complicated and tough to replicate in static in vitro culture systems. Simultaneous culture of three organs while retaining in vivo functionalities is difficult and often not reproducible. Two-dimensional, static models also lack the ability to measure pharmacokinetic and pharmacodynamic parameters from drug and metabolite flow from the gut to the liver to the kidney.
Organ chips are translational models that can bridge the gap between in vitro and in vivo analysis of cell and drug interactions. By providing a dynamic environment, the fluid flow recapitulates physiological cell functions and even replicates the natural flow and processing of drugs from organ to organ.
