- Products & Services
OrganRXTM Tissue builds quality, transplantable tissue for organ repair needs. Using the advanced biomimetic OrganRXTM technologies allows for the construction of functional organ tissue for therapeutic discoveries.
The multi-organ recirculation system (OrganRXTM) provides passive gravity-driven unidirectional shear flow to multi-organ culture. The OrganRXTM plate can accommodate multiple micro-organs such as liver, gut, kidney and brain.
The organ plate is an injection molded glass bottom disposable plate. The users can populate the plate with primary cells, cell lines or IPS cells and mature organs by media recirculation. Currently the plate has six multi-organ units.
We provide testing of compounds in 2-D and 3-D blood-brain-barrier tissue models. OrganRXTM enables determination of transport characteristics of novel compounds to/from the brain and other organs. - Applications
Applications
OrganRXTM helps to recapitulate human organs with physiological, mechanical and biochemical complexities and their interaction through the exchange of metabolites or signaling molecules and selective transport across the barriers.
Organ Functions
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Gut Plate
The gut consists mainly of the intestine, which is made up of endothelial and epithelial cells as well as a host of microbiota. The complex microbiota of the gut has been shown to functionally contribute to multiple organs in recent research. It can even play roles in the pathology of a number of conditions and diseases. Also, drugs entering the digestive pathway are often metabolized by the gut and its diverse microbiota.
Animal models of the gut are difficult to compare to human data due to the differences in ecological characteristics. Since the immune system is also implicated with the gut, contrasts in these systems between animals and humans have made it challenging to extrapolate from gathered animal and in vitro data. Differences in drug metabolism in the gut have also contributed to differences in pre-clinical and clinical testing of therapeutic compounds.
Studying the unique intricacies of the gut require in vitro models that can simulate dynamic in vivo flow and house the diverse cellular systems that comprise the gut. The three-dimensional compatibility of microfluidic chips facilitates cells to recapitulate organ-like functions and provide physiologically-relevant data.
