Category: Translational Risk Mechanisms

Excessive immune activation by biologic therapies can trigger uncontrolled cytokine release, causing systemic inflammation and multi-organ complications.

Immune-targeting biologics may bind the intended antigen on tumors but also attack healthy tissues that express the same antigen, leading to unintended organ toxicity.

Biologic drugs may fail to reach all cancer cells due to poor tissue penetration and uneven target expression within tumors, limiting therapeutic effectiveness.

Cytotoxic payloads released from targeted therapies can diffuse into neighboring cells that do not express the target antigen, resulting in unintended tissue damage.