- Products & Services
OrganRXTM Tissue builds quality, transplantable tissue for organ repair needs. Using the advanced biomimetic OrganRXTM technologies allows for the construction of functional organ tissue for therapeutic discoveries.
The multi-organ recirculation system (OrganRXTM) provides passive gravity-driven unidirectional shear flow to multi-organ culture. The OrganRXTM plate can accommodate multiple micro-organs such as liver, gut, kidney and brain.
The organ plate is an injection molded glass bottom disposable plate. The users can populate the plate with primary cells, cell lines or IPS cells and mature organs by media recirculation. Currently the plate has six multi-organ units.
We provide testing of compounds in 2-D and 3-D blood-brain-barrier tissue models. OrganRXTM enables determination of transport characteristics of novel compounds to/from the brain and other organs. - Applications
Applications
OrganRXTM helps to recapitulate human organs with physiological, mechanical and biochemical complexities and their interaction through the exchange of metabolites or signaling molecules and selective transport across the barriers.
Organ Functions
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Brain Plate
The components of the brain can be cultured in vitro to simulate the physiological and electrical properties of the human brain. When cultured along with cell systems of the BBB, the movement of molecules and ions between the blood and the brain can be evaluated. Neurons from different regions or neuronal stem cells can be grown and differentiated to construct a functional three-dimensional brain unit.
Brain models on 2-D platforms prevent multiple cultures of brain cells and limit parameters like shear stress from being studied. In addition, animal models of neurological conditions, particularly Alzheimer’s Disease, are not completely comparable with human data and mostly provide end-point data. There is a lack of in vitro models that can demonstrate the disease progression of neurological conditions.
Culturing the brain on 3-D microfluidic models not only stimulates cells to adopt in vivo physiology and form organ-like structures but also provides a disease-modeling platform that can track ongoing pathology. Adding the BBB constructs a platform suitable for drug screening and development.
