- Products & Services
OrganRXTM Tissue builds quality, transplantable tissue for organ repair needs. Using the advanced biomimetic OrganRXTM technologies allows for the construction of functional organ tissue for therapeutic discoveries.
The multi-organ recirculation system (OrganRXTM) provides passive gravity-driven unidirectional shear flow to multi-organ culture. The OrganRXTM plate can accommodate multiple micro-organs such as liver, gut, kidney and brain.
The organ plate is an injection molded glass bottom disposable plate. The users can populate the plate with primary cells, cell lines or IPS cells and mature organs by media recirculation. Currently the plate has six multi-organ units.
We provide testing of compounds in 2-D and 3-D blood-brain-barrier tissue models. OrganRXTM enables determination of transport characteristics of novel compounds to/from the brain and other organs. - Applications
Applications
OrganRXTM helps to recapitulate human organs with physiological, mechanical and biochemical complexities and their interaction through the exchange of metabolites or signaling molecules and selective transport across the barriers.
Organ Functions
MenuOrgan Models
Menu
Brain-Kidney Plate
Drugs targeting the brain typically have to cross the blood-brain barrier. But before drugs enter the brain, they are usually processed and metabolized by the liver. The continuous flow of drugs and their active metabolites from the liver to the brain is crucial to assess cytotoxicity in either or both organs.
The liver and brain are implicated in a number of inflammation pathways, but static, two-dimensional culture models are unable to facilitate the live organ-brain crosstalk. In addition, drugs tested on these models do not follow the physiological flow of drug compounds and metabolites from liver to brain, possibly impacting pharmacological activity.
Dynamic, three-dimensional models, like organ chips, that can recreate the flow of drugs from metabolism in the liver to passing the BBB and targeting the brain are crucial for drug development. The pharmacokinetic activity of drugs can be studied in real time as the compounds, and their active metabolites circulate through the organs.
